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Canonical T cell receptor docking on peptide–MHC is essential for T cell signaling

Making sense of TCR–pMHC topology Most T cells use a T cell receptor (TCR) that recognizes major histocompatibility complex molecules…

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Science

Structure reveals the activation mechanism of the MC4 receptor to initiate satiation signaling

To eat or not to eat Melanocortin receptor 4 (MC4R) plays a role in regulating food intake: Its activation by…

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